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bp0018cpr31 | Control of Prenatal Development | CPR2009

Development of the pig placenta*

Vallet J.L. , Miles J.R. , Freking B.A. ,

Placental insufficiency results in fetal loss, low birth weight, stillbirth, preweaning mortality and poor growth. Placental development begins at conceptus elongation, which is a primary factor controlling the size of the placenta. After elongation, the allantois develops outward from the embryo to establish the al lantochorion, which defines the size of the functional placenta. During implantation, chorionic trophoblasts adhere to endometrial epithelial cells. Placenta...

bp0018cpr30 | Control of Prenatal Development | CPR2009

Functional genomic approaches for the study of fetal/placental development in swine with special emphasis on imprinted genes

Bischoff S.R. , Tsai S. , Hardison N. , Motsinger-Reift A.A. , Freking B.A. , Piedrahita J.A.

This chapter describes the application of functional genomic approaches to the study of imprinted genes in swine. While there are varied definitions of "functional genomics", in general they focus on the application of DNA microarrays, single nucleotide polymorphism (SNP) arrays, and other high coverage genomic analyses, and their combination with downstream methods of gene modification such as silencing RNA (siRNA) and viral and non-viral transfection. Between the initi...